Optimizing mechanical ventilation in cardiac failure.

The use of progressively more complex mathematical models that can account in detail for ventilation mechanics would help the clinician to devise the optimal therapeutic strategy (in terms of Positive End-Expiratory Pressure, Tidal volumes or Peak Inspiratory Pressure) to maximize alveolar recruitment minimizing Ventilation-Induced Lung Injury. This approach is particularly promising when dealing with pulmonary stiffness caused by (relative) cardiac failure.

This work is conducted in collaboration with medical doctors in Budapest and involves both model construction and real-time model identification from on-line patient data.